A rare manifestation of hypothyroid myopathy: Hoffmann's syndrome
- Authors
- Lee K.W.; Kim S.H.; Kim K.J.; Kim S.H.; Kim H.Y.; Kim B.-J.; Kim S.G.; Choi D.S.
- Issue Date
- Dec-2015
- Publisher
- Korean Endocrine Society
- Keywords
- Creatine kinase; Hypothyroidism; Muscular diseases
- Citation
- Endocrinology and Metabolism, v.30, no.4, pp 626 - 630
- Pages
- 5
- Indexed
- SCOPUS
KCI
- Journal Title
- Endocrinology and Metabolism
- Volume
- 30
- Number
- 4
- Start Page
- 626
- End Page
- 630
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/30156
- DOI
- 10.3803/EnM.2015.30.4.626
- ISSN
- 2093-596X
2093-5978
- Abstract
- Hypothyroid myopathy is observed frequently and the resolution of the clinical manifestations of myopathy following thyroid hormone replacement is well known. However, a specific subtype of hypothyroid myopathy, Hoffmann's syndrome, characterized by increased muscular mass (pseudohypertrophy), proximal muscle weakness, muscle stiffness and cramps, is rarely reported. Herein, we describe a 34-year-old male who presented with proximal muscle weakness and non-pitting edema of the lower extremities. He initially visited the neurology department where he was suspected of having polymyositis. Additional laboratory evaluation revealed profound autoimmune hypothyroidism and elevated muscle enzymes including creatine kinase. The patient was started on levothyroxine treatment and, subsequently, clinical symptoms and biochemical parameters resolved with the treatment. The present case highlights that hypothyroidism should be considered in the differential diagnosis of musculoskeletal symptoms even in the absence of overt manifestations of hypothyroidism. To our knowledge, this is the first case reported in Korea. © 2015 Korean Endocrine Society.
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- Appears in
Collections - 2. Clinical Science > Department of Neurology > 1. Journal Articles
- 2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
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