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Cited 8 time in webofscience Cited 12 time in scopus
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Chronic Hepatitis B Infection Is Significantly Associated with Chronic Kidney Disease: a Population-based, Matched Case-control Studyopen access

Authors
Kim, Sung-EunJang, Eun SunKi, MoranGwak, Geum-YounKim, Kyung-AhKim, Gi-AeKim, Do YoungKim, Dong JoonKim, Man WooKim, Yun SooKim, Young SeokKim, In HeeKim, Chang WookKim, Ho DongKim, Hyung JoonPark, Neung HwaBaik, Soon KooSuh, Jeong IllSong, Byung-CheolSong, Il HanYeon, Jong EunLee, Byung SeokLee, Youn JaeJung, Young KulChung, Woo JinCho, Sung BumCho, Eun-YoungCho, Hyun ChinCheon, Gab JinChae, Hee BokChoi, DaeHeeChoi, Sung-KyuChoi, Hwa YoungTak, Won YoungHeo, JeongJeong, Sook-Hyang
Issue Date
15-Oct-2018
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Hepatitis B Virus; Chronic Renal Insufficiency; Glomerular Filtration Rate; Proteinuria
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.42
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
33
Number
42
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3026
DOI
10.3346/jkms.2018.33.e264
ISSN
1011-8934
Abstract
Background: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. Methods: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age-and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m(2) or proteinuria as at least grade 2+ of urine protein. Results: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m(2) (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m(2) along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m(2). Conclusion: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m(2) and proteinuria (>= 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.
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Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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