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Cited 8 time in webofscience Cited 8 time in scopus
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Three distinct genomic subtypes of head and neck squamous cell carcinoma associated with clinical outcomes

Authors
Lee, Dong JinEun, Young-GyuRho, Young SooKim, Eui HyunYim, Sun YoungKang, Sang HeeSohn, Bo HwaKwon, Gee HwanLee, Ju-Seog
Issue Date
Oct-2018
Publisher
ELSEVIER SCIENCE BV
Keywords
Molecular subtypes; Pan-SCCs; HNSCCs; TCGA; RNAseq
Citation
ORAL ONCOLOGY, v.85, pp.44 - 51
Indexed
SCIE
SCOPUS
Journal Title
ORAL ONCOLOGY
Volume
85
Start Page
44
End Page
51
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3057
DOI
10.1016/j.oraloncology.2018.08.009
ISSN
1368-8375
Abstract
Objectives: Heterogeneity of head and neck squamous cell carcinomas (HNSCCs) results in unpredictable outcomes for patients with similar stages of cancer. Beyond the role of human papilloma virus (HPV), no validated molecular marker of HNSCCs has been established. Thus, clinically relevant molecular subtypes are needed to optimize HNSCC therapy. The purpose of this study was to identify subtypes of HNSCC that have distinct biological characteristics associated with clinical outcomes and to characterize genomic alterations that best reflect the biological and clinical characteristics of each subtype. Materials and methods: We analyzed gene expression profiling data from pan-SCC tissues including cervical SCC, esophageal SCC, lung SCC, and HNSCC (n = 1346) to assess the similarities and differences among SCCs and to identify molecular subtypes of HNSCC associated with prognosis. Subtype-specific gene expression signatures were identified and used to construct predictive models. The association of the subtypes with prognosis was validated in two independent cohorts of patients. Results: Pan-SCC analysis identified three novel subtypes of HNSCC. Subtype 1 had the best prognosis and was similar to cervical SCC, whereas subtype 3 had the worst prognosis and was similar to lung SCC. Subtype 2 had a moderate prognosis. The 600-gene signature associated with the three subtypes significantly predicted prognosis in two independent validation cohorts. These three subtypes also were associated with potential benefit of immunotherapy. Conclusion: We identified three clinically relevant HNSCC molecular subtypes. Independent prospective studies to assess the clinical utility of the subtypes and associated gene signature are warranted.
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Kang, Sang hee
구로병원 (Department of Colon and Rectal Surgery, Guro Hospital)
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