Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007-2014
- Authors
- Noh, Ji Yun; Choi, Won Suk; Song, Joon Young; Lee, Han Sol; Lim, Sooyeon; Lee, Jacob; Seo, Yu Bin; Lee, Jin-Soo; Wie, Seong-Heon; Jeong, Hye Won; Heo, Jung Yeon; Kim, Young Keun; Park, Kyung Hwa; Kim, Shin Woo; Lee, Sun Hee; Lee, Jung Hwa; Kim, Dong Hyun; Woo, Sung Il; Lim, Chae Seung; Cho, Kyung Soon; Cheong, Hee Jin; Kim, Woo Joo
- Issue Date
- Aug-2018
- Publisher
- Elsevier BV
- Keywords
- Epidemiology; Influenza B virus
- Citation
- Vaccine, v.36, no.35, pp 5304 - 5308
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Vaccine
- Volume
- 36
- Number
- 35
- Start Page
- 5304
- End Page
- 5308
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3251
- DOI
- 10.1016/j.vaccine.2018.07.021
- ISSN
- 0264-410X
1358-8745
- Abstract
- We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007–2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007–2008 season to 2013–2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages.
A total of 571 influenza B virus sequences were analyzed. During the 2009–2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007–2008, 2011–2012, and 2013–2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain.
During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.
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Collections - 2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Pediatrics > 1. Journal Articles
- 4. Research institute > Asian Pacific Influenza Institute > 1. Journal Articles
- 2. Clinical Science > Department of Infectious Diseases > 1. Journal Articles
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