Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis.
- Authors
- Lee J.H.; Yang H.M.; Bak U.B.; Rim H.J.
- Issue Date
- 1994
- Citation
- The Korean journal of parasitology, v.32, no.1, pp 13 - 18
- Pages
- 6
- Indexed
- SCOPUS
- Journal Title
- The Korean journal of parasitology
- Volume
- 32
- Number
- 1
- Start Page
- 13
- End Page
- 18
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/32747
- DOI
- 10.3347/kjp.1994.32.1.13
- ISSN
- 0023-4001
1738-0006
- Abstract
- Chronic Clonorchis sinensis (CS) infection is etiologically related to cholangiocarcinoma (CHCA) in human and animals. This study was carried out to clarify the role of CS infection on dimethylnitrosamine (DMN)-induced cholangiocarcinogenesis. Fifteen hamsters were administered with 15 ppm DMN for 4 weeks and one week later, the hamsters were infected with 15 metacercariae of CS (DMN-->CS group). The other 15 hamsters were infected with CS and after 5 weeks they were treated with the drug, praziquantel. Again one week later, the hamsters were administered with DMN (CS-->DMN group). The other 15 hamsters were administered with DMN and CS simultaneously (CS+DMN group). Histopathological examination of the livers showed CHCA with papillary or adenomatous hyperplasia of bile ductules in 3 of 15 hamsters of DMN-->CS group and in 11 of 15 hamsters of DMN+CS group. These results suggest that CS infection to hamsters may have a promoting effect on the development of CHCA.
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Collections - 1. Basic Science > Department of Parasitology > 1. Journal Articles
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