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Effects of long-term propranolol administration on systemic and portal hemodynamics in rats in the development stage of liver cirrhosis induced by CCL4
- Authors
- Nishida O.; Um S.H.; Tokubayashi M.; Kimura F.; Takimoto Y.; Yoshioka H.; Inoue R.; Murakami M.; Kita T.
- Issue Date
- Dec-1993
- Keywords
- liver cirrhosis; microsphere sampling method; portal hypertension; propranolol; rat
- Citation
- Japanese Archives of Internal Medicine, v.41, no.1, pp 1 - 8
- Pages
- 8
- Indexed
- SCOPUS
- Journal Title
- Japanese Archives of Internal Medicine
- Volume
- 41
- Number
- 1
- Start Page
- 1
- End Page
- 8
- ISSN
- 0021-4809
- Abstract
- The effects of oral continual administration of propranolol on systemic and portal hemodynamics were studied in cirrhotic rats induced by subcutaneous injection of carbon tetrachloride. Compared with non-administered cirrhotic group, long-term administered cirrhotic group was found to have a significant decrease of portal venous pressure and intrahepatic portal resistance. But portal venous inflow and splanchnic arterial resistance were not significantly different between the two groups. Therefore, the long-term administration of propranolol decreased portal venous pressure by prevention of the elevation of intrahepatic portal resistance without affecting portal venous inflow. So we conclude that long-term administration of propranolol in the development stage of liver cirrhosis might be a good choice for treatment of portal hypertension
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