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A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B

Authors
Kim, DongwooLee, JongjinKim, Dae-haKang, KyuhoSuh, Sang JunJung, Young KulYim, Hyung Joon
Issue Date
Dec-2016
Keywords
Fanconi syndrome; Hepatitis B virus; Kidney tubules, proximal; Osteomalacia; Tenofovir
Citation
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.68, no.6, pp 317 - 320
Pages
4
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume
68
Number
6
Start Page
317
End Page
320
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/33282
DOI
10.4166/kjg.2016.68.6.317
ISSN
1598-9992
2233-6869
Abstract
Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity have been reported in the treatment of HIV patients. Even more recently, very few cases of Fanconi syndrome associated with tenofovir therapy in HBV monoinfection have been reported. Herein, we report a case of a 47-year-old male with an HBV monoinfection, who developed Fanconi syndrome and a secondary osteomalacia with multiple bone pain. After TDF withdrawal and supplementation of calcitriol, his renal function was reverted. Although the overall risk of TDF-associated nephrotoxicity is very low, both glomerular and tubular function should be monitored in patients undergoing TDF treatment.
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Jung, Young Kul
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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