Detailed Information

Cited 5 time in webofscience Cited 5 time in scopus
Metadata Downloads

Identification of novel susceptibility loci associated with hepatitis B surface antigen seroclearance in chronic hepatitis B

Authors
Kim, Tae HyungLee, Eun-JuChoi, Ji-HyeYim, Sun YoungLee, SunwonKang, JaewooLee, Yoo RaLee, Han AhChoi, Hyuk SoonKim, Eun SunKeum, BoraSeo, Yeon SeokYim, Hyung JoonJeen, Yoon TeeChun, Hoon JaiLee, Hong SikKim, Chang DuckWoo, Hyun GooUm, Soon Ho
Issue Date
Jul-2018
Publisher
Public Library of Science
Citation
PLoS ONE, v.13, no.7
Indexed
SCIE
SCOPUS
Journal Title
PLoS ONE
Volume
13
Number
7
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3338
DOI
10.1371/journal.pone.0199094
ISSN
1932-6203
Abstract
Background/Aims The seroclearance of hepatitis B virus (HBV) surface antigen (HBsAg) is regarded as a functional cure of chronic hepatitis B (CHB) although it occurs rarely. Recently, several genome-wide association studies (GWASs) revealed various genetic alterations related to the clinical course of HBV infection. However, all of these studies focused on the progression of HBV infection to chronicity and had limited application because of the heterogeneity of HBV genotypes. In the present study, we aimed to determine susceptibility genetic markers for seroclearance of HBsAg in CHB patients with a homogenous viral genotype. Methods One hundred patients with CHB who had experienced HBsAg seroclearance before 60 years of age and another 100 with CHB showing high serum levels of HBsAg even after 60 years of age were enrolled. Extreme-phenotype GWAS was conducted using blood samples of participants. Results We identified three single nucleotide polymorphisms, rs7944135 (P = 4.17 × 10−6, odds ratio [OR] = 4.16, 95% confidence interval [CI] = 2.27–7.63) at 11q12.1, rs171941 (P = 3.52×10−6, OR = 3.69, 95% CI = 2.13–6.42) at 5q14.1, and rs6462008 (P = 3.40×10−6, OR = 0.34, 95% CI = 0.22–0.54) at 7p15.2 as novel susceptibility loci associated with HBsAg seroclearance in patients with CHB. The flanking genes at these loci including MPEG1, DTX4, MTX3, and HOXA13 were suggested to have functional significance. In addition, through functional analysis, CXCL13 was also presumed to be related. Conclusions To the best of our knowledge, this study is the first GWAS regarding the seroclearance of HBsAg in CHB patients. We identify new susceptibility loci for cure of CHB, providing new insights into its pathophysiology.
Files in This Item
There are no files associated with this item.
Appears in
Collections
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jeen, Yoon Tae photo

Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE