Prostaglandin E2 (PGE2): Roles in Immune Responses and Inflammation
- Authors
- 지종대; 이영호; 장현규
- Issue Date
- Dec-2004
- Keywords
- Prostaglandin E2; Inflammation; Immune modulation
- Citation
- 대한류마티스학회지, v.11, no.4, pp 307 - 316
- Pages
- 10
- Indexed
- KCICANDI
- Journal Title
- 대한류마티스학회지
- Volume
- 11
- Number
- 4
- Start Page
- 307
- End Page
- 316
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/33515
- ISSN
- 2093-940X
2233-4718
- Abstract
- Prostaglandins have numerous biologic effects on a variety of physiological and pathological activities such as inflammation, platelet aggregation, neurotransmitter release, smooth muscle contraction, and so forth. PGE2 is one of the well-studied inflammatory prostaglandins and causes vasodilatation, edema, fever and pain. Also PGE2 induces the production of matrix metalloproteinases (MMPs) which involve in destruction of tissue. In rheumatoid arthritis, macrophages isolated from patients secrete large amounts of PGE2 and PGE2 promote inflammation and participate in destructive mechanisms of the rheumatoid joint. In addition to its proinflammatory effects, PGE2 acts also as an immunomodulator, promote humoral and Th2-type immune responses and inhibit Th1-type immune responses. Also PGE2 inhibits the production of tumor necrosis factor (TNF-α), IL-1β, IL-8 and IL-12 and stimulates the production of IL-10 by macrophages. Thus PGE2 should be regarded not as proinflammatory molecule but as modulator of immune responses. In this review, we will focus on the current knowledge about PGE2 as the modulator of immune responses and summarize the effects of PGE2 on the immune systems and inflammation.
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- Appears in
Collections - 2. Clinical Science > Department of Rheumatology > 1. Journal Articles
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