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Analysis of Anticancer Activity and Chemical Sensitization Effects of Dendropanax morbifera and Commersonia bartramia Extractsopen access

Authors
Kim, SeongminPark, Sung GyuSong, Yoon JaePark, Jeong KooChoi, Cheol HeeLee, SanghoonHoffman, Robert M.
Issue Date
Jul-2018
Publisher
INT INST ANTICANCER RESEARCH
Keywords
Chemical sensitivity; cytotoxicity; drug response; Dendropanax; Commersonia
Citation
ANTICANCER RESEARCH, v.38, no.7, pp.3853 - 3861
Indexed
SCIE
SCOPUS
Journal Title
ANTICANCER RESEARCH
Volume
38
Number
7
Start Page
3853
End Page
3861
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3401
DOI
10.21873/anticanres.12669
ISSN
0250-7005
Abstract
Background/Aim: Dendropanax morbifera (DM) and Commersonia bartramia (CB) are possible candidates for immunotherapy. In this study, the cytotoxicity and chemical sensitization of DM and CB extracts on gynecologic and colon cancers were evaluated. Materials and Methods: The malignant cell lines were cultured and analyzed for cytotoxicity and chemical sensitization. A mouse model was also constructed to make the condition similar to in vivo. Reverse transcriptionpolymerase chain reaction was conducted to determine alterations in drug-resistant genes. Results: The extracts from DM and CB showed specific cytotoxicity to malignant cell lines. DM increased chemical sensitivity to cervical and ovarian cancer, while CB showed improved sensitization to endometrial cancer. The effects of the extracts were confirmed using a mouse model. The extracts induced differences in the expression levels of a number of genes related to drug resistance. Conclusion: DM and CB extracts could be novel agents for immunotherapy and chemical sensitization in gynecologic and colon cancers.
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Lee, Sang hoon
Anam Hospital (Department of Obstetrics and Gynecology, Anam Hospital)
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