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Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantationopen access
- Authors
- Kim, Nayoung; Yoon, Young-In; Yoo, Hyun Ju; Tak, Eunyoung; Ahn, Chul-Soo; Song, Gi-Won; Lee, Sung-Gyu; Hwang, Shin
- Issue Date
- Aug-2016
- Publisher
- 한국분자세포생물학회
- Keywords
- acute rejection; biomarker; chemokine; cytokine; liver transplant
- Citation
- Molecules and Cells, v.39, no.8, pp 639 - 644
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
KCI
- Journal Title
- Molecules and Cells
- Volume
- 39
- Number
- 8
- Start Page
- 639
- End Page
- 644
- ISSN
- 0219-1032
- Abstract
- Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the sera from liver transplant patients as potential biomarkers for acute rejection, and found that the combined detection of IL-10, IL-17, and CXCL10 at 1-2 weeks post-operation could predict acute rejection following adult liver transplantation with 97% specificity and 94% sensitivity.
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