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Pep-1 Peptide-Modified Liposomal Carriers for Intracellular Delivery of Gold Nanoparticles
- Authors
- Kang, Myung Joo; Lee, Sangyeop; Km, Bo Kyun; Eum, Jae Yoon; Park, Sang Han; Kang, Min Hyung; Oh, Chil Hwan; Choo, Jaebum; Choi, Young Wook
- Issue Date
- Jan-2011
- Publisher
- Pharmaceutical Society of Japan
- Keywords
- gold nanoparticle; liposome; Pep 1 peptide; nanocarrier; intracellular delivery
- Citation
- Chemical and Pharmaceutical Bulletin, v.59, no.1, pp 109 - 112
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Chemical and Pharmaceutical Bulletin
- Volume
- 59
- Number
- 1
- Start Page
- 109
- End Page
- 112
- ISSN
- 0009-2363
1347-5223
- Abstract
- A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to Increase the intracellular delivery of gold nanoparticles (Au NPs) Au NPs with a mean diameter of 13 nm were successfully encapsulated Into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm The Au NP-loaded liposomal carrier was physically characterized as 150-170 nm in size and 45 mV in zeta potential Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes Into the cells was Increased by Pep1-Lipo carriers compared to bare Au NPs In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs
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Collections - 2. Clinical Science > Department of Dermatology > 1. Journal Articles
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Related Researcher
- Oh, Chil Hwan
- Guro Hospital (Department of Dermatology, Guro Hospital)