The antifibrotic effect of TGF-beta 1 siRNAs in murine model of liver cirrhosis
- Authors
- Kim, KH; Kim, HC; Hwang, MY; Oh, HK; Lee, TS; Chang, YC; Song, HJ; Won, NH; Park, KK
- Issue Date
- 19-May-2006
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- TGF-beta 1; RNA interference; siRNA; liver cirrhosis
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.343, no.4, pp 1072 - 1078
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 343
- Number
- 4
- Start Page
- 1072
- End Page
- 1078
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/36099
- DOI
- 10.1016/j.bbrc.2006.03.087
- ISSN
- 0006-291X
1090-2104
- Abstract
- Liver fibrosis results from chronic damage to the liver by chronic hepatitis, alcohol, and toxic agents. A characteristic of liver fibrosis is an accumulation of extracellular matrix (ECM) protein, which distorts the hepatic architecture by forming a fibrous scar, and the subsequent development of regenerating nodules defines cirrhosis. Transforming growth factor (TGF)-beta 1, one of the most powerful profibrogenic mediators, plays a major role in the development of liver cirrhosis and regulates ECM gene expression and matrix degradation. This study elucidates the changes of TGF-beta 1-mediated signals during liver fibrogenesis by using RNA interference. In this experiment, the TGF-beta 1 siRNAs reduced the expression of TGF-beta 1 in the livers of CCl4 injection compared with those of control group, and the expression of type I collagen and a-smooth muscle actin was decreased. In conclusion, this study demonstrates that TGF-beta 1 siRNAs inhibit TGF-beta 1 expression in the murine model of liver cirrhosis and might be a good therapeutic strategy to prevent liver cirrhosis in human. beta 2006 Elsevier Inc. All rights reserved.
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Collections - 1. Basic Science > Department of Pathology > 1. Journal Articles
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