Pax5 expression in non-Hodgkin's lymphomas and acute leukemias
- Authors
- Zhang, XL; Lin, ZH; Kim, IS
- Issue Date
- Dec-2003
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- B cell activation antigen; lymphoma; non-Hodgkin; leukemia; B-cell; acute; leukemia; myelocytic; acute; multiple myeloma
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.18, no.6, pp 804 - 808
- Pages
- 5
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 18
- Number
- 6
- Start Page
- 804
- End Page
- 808
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/36664
- DOI
- 10.3346/jkms.2003.18.6.804
- ISSN
- 1011-8934
1598-6357
- Abstract
- The Pax5 gene encodes the B-cell-specific activator protein which is a key regulator in development and differentiation of B-cell. We studied the expression of Pax5 in hematologic malignancies to evaluate the diagnostic utility as a B cell marker. Materials included 70 B cell lymphomas, 26 T cell lymphomas, 53 acute leukemias,and 6 multiple myelomas (MMs). Representative areas from the paraffin-embedded tissues were selected for tissue microarray, and the expressions of Pax5 was immunohistochemically evaluated. Pax5 was strongly expressed in most of the B cell lymphomas; 44 of 47 diffuse large B cell lymphomas (93.6%), 15 of 16 marginal zone B cell lymphomas (93.8%), all 3 mantle cell lymphomas, 2 follicular lymphomas, and 2 Burkitt's lymphomas (100%). However, Pax5 was expressed in only one of 26 T cell lymphomas. Among leukemias, it was expressed in 10 of the 14 B acute lymphocytic leukemias (ALLs) (72.4%), but also in 3 of the 6 T ALLs (50%), 13 of the 26 acute myelogenous leukemias (AMLs) (50%) and in all 3 ALL arising in chronic myelogenous leukemias and 4 mixed B ALL and AML. In Pax5 was negative in all cases. We concluded that Pax5 is very useful B MMs, cell marker in classification of lymphomas, but not of acute leukemias.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 1. Basic Science > Department of Pathology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.