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Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats
- Issue Date
- 15-May-2003
- Publisher
- ELSEVIER SCI IRELAND LTD
- Keywords
- vasoactive polypeptide; neuropeptide Y; neuropathic pain; peripheral neuropathy; dorsal horn; allodynia
- Citation
- NEUROSCIENCE LETTERS, v.342, no.1-2, pp 109 - 113
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROSCIENCE LETTERS
- Volume
- 342
- Number
- 1-2
- Start Page
- 109
- End Page
- 113
- ISSN
- 0304-3940
1872-7972
- Abstract
- We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain. To this aim, we compared two groups of rats. One group showed well-developed neuropathic pain in the tail following unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves, and the other group showed poorly-developed neuropathic pain despite the same nerve injury. The increases in immunoreactivity of VIP and NPY in the S I dorsal hom (injured segment) were not significantly different between the two groups. These results suggested that increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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Collections - 1. Basic Science > Department of Physiology > 1. Journal Articles
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Related Researcher
- Na, Heung Sik
- College of Medicine (Department of Physiology)