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Changes in premenstrual symptoms in women with schizophrenia: A prospective study

Authors
Choi, SHKang, SBJoe, SH
Issue Date
Sep-2001
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
premenstrual symptom change; schizophrenia; premenstrual syndrome; estrogen; Daily Rating Form; Brief Psychiatric Rating Scale
Citation
PSYCHOSOMATIC MEDICINE, v.63, no.5, pp.822 - 829
Indexed
SCIE
SCOPUS
Journal Title
PSYCHOSOMATIC MEDICINE
Volume
63
Number
5
Start Page
822
End Page
829
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/37211
DOI
10.1097/00006842-200109000-00016
ISSN
0033-3174
Abstract
Objective: We investigated whether the psychiatric symptoms and clinical features of schizophrenia change during the premenstrual phase in female patients. Methods: We observed 30 female schizophrenic inpatients over one menstrual cycle. All subjects met DSM-IV criteria for schizophrenia, and all had a regular menstrual cycle. All subjects completed the Daily Rating Form (DRF) every evening, and one psychiatrist rated the subjects (using the Brief Psychiatric Rating Scale [BPRS]) once during each of the three menstrual phases (premenstrual, menstrual, and postmenstrual). Serum levels of estradiol (E-2) and progesterone were measured on the fifth to seventh day of both the premenstrual and postmenstrual phases. Data from the 24 subjects who completed the DRF correctly and completely were used for statistical analysis. Results: The mean total BPRS score for the 24 subjects was highest in the premenstrual phase and lowest in the postmenstrual. phase, and a statistically significant difference was found among the three menstrual phases. Mean subtotal BPRS scores showed statistically significant differences among the three menstrual phases in anxiety/depression and withdrawal/retardation, but not in the psychotic symptom subscales. Mean serum E-2 level showed a trend of increasing from the premenstrual phase to the postmenstrual phase. However, there was no significant correlation between Delta BPRS and DeltaE(2). When the criterion of 30% change was applied, the DRF items of depressed mood, anxious/nervous/restless, hostile/aggressive, and less/impaired work showed high frequencies of change in the premenstrual phase. Somatic items of abdominal pain, breast pain, and headache showed significant change with the 30% change rule on the DRF. On both the BPRS and DRF scores, premenstrual change of affective and behavioral symptoms was prominent, whereas the change of psychotic symptoms was minimal on the BPRS. In addition, in the premenstrual phase, there was a statistically significant correlation between the total BPRS score and the mean total DRF score. There was no correlation between premenstrual change in symptoms and hormonal levels of E-2, progesterone, and the estradiol/progesterone (E/P) ratio. Conclusions: The findings of this study suggest that premenstrual exacerbation of schizophrenic symptoms in female patients may not be a worsening of the schizophrenic symptoms but a concurrence of affective, behavioral, and somatic symptoms.
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