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Decrease in spinal CGRP and substance P is not related to neuropathic pain in a rat model
- Issue Date
- 22-Jan-2001
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- allodynia; calcitonin gene-related peptide; neuropathic pain; peripheral nerve injury; peripheral neuropathy; substance P
- Citation
- NEUROREPORT, v.12, no.1, pp 175 - 178
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROREPORT
- Volume
- 12
- Number
- 1
- Start Page
- 175
- End Page
- 178
- ISSN
- 0959-4965
1473-558X
- Abstract
- We tested the hypothesis that the decrease in spinal levels of SP and CGRP after peripheral nerve injury is related to neuropathic pain. We compared two groups of rats, both of which were subjected to unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves. One group exhibited well-developed neuropathic signs after the nerve injury, whereas the other group showed poorly developed signs despite the same nerve injury. The decrease in immunoreactivity of CGRP and SP in the SI dorsal horn (injured segment) was not significantly different between the two groups. These results suggest that the decrease in spinal levels of CGRP and SP after peripheral nerve injury is not related to neuropathic pain. NeuroReport 11:175-178 (C) 2001 Lippincott Williams & Wilkins.
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Collections - 1. Basic Science > Department of Physiology > 1. Journal Articles
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Related Researcher
- Na, Heung Sik
- College of Medicine (Department of Physiology)