Detailed Information

Cited 45 time in webofscience Cited 53 time in scopus
Metadata Downloads

The significance of microsatellite instability in colorectal cancer after controlling for clinicopathological factors

Authors
Kang, SangheeNa, YounghyunJoung, Sung YupLee, Sun IlOh, Sang CheulMin, Byung Wook
Issue Date
Mar-2018
Publisher
Lippincott Williams & Wilkins Ltd.
Keywords
colorectal neoplasms; microsatellite instability; propensity score; survival
Citation
Medicine, v.97, no.9
Indexed
SCIE
SCOPUS
Journal Title
Medicine
Volume
97
Number
9
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3792
DOI
10.1097/MD.0000000000010019
ISSN
0025-7974
Abstract
The colorectal cancer (CRC) patients with microsatellite instability (MSI) have distinct clinicopathological characteristics consisting of factors predicting positive and negative outcomes, such as a high lymph node harvest and poor differentiation. In this study, we measured the value of MSI as a prognostic factor after controlling for these discrepant factors. A total of 603 patients who underwent curative surgery for stages I to III colorectal cancer were enrolled. The patients were divided into microsatellite instability high (MSI-H) and microsatellite stable/microsatellite instability low (MSS/MSI-L) groups. Propensity score matching was used to match clinicopathological factors between the 2 groups. MSI-H patients had a high lymph node harvest (median: 31.0 vs 23.0, P<.001), earlier-stage tumors (P<.001), advanced T stage (89.3% vs 74.0%, P=.018), and poor differentiation (19.6% vs 2.0%, P<.001). Survival analysis showed better survival in the MSI-H group, but the difference was not statistically significant (P=.126). Propensity score matching was performed for significant prognostic factors identified by Cox hazard regression. After the matching, the survival difference by MSI status was estimated to be larger than before, and reached statistical significance (P=.045). In conclusion, after controlling for pathological characteristics, MSI-H could be a potent prognostic factor regarding patient survival.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kang, Sang hee photo

Kang, Sang hee
구로병원 (Department of Colon and Rectal Surgery, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE