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Hyponatremia in Liver Cirrhosis

Authors
Jang, CheolminJung, Young Kul
Issue Date
Aug-2018
Publisher
NLM (Medline)
Keywords
Antidiuretic hormone receptor antagonists; Hypertension portal; Hyponatremia; Liver cirrhosis
Citation
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.72, no.2, pp.74 - 78
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume
72
Number
2
Start Page
74
End Page
78
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4158
DOI
10.4166/kjg.2018.72.2.74
ISSN
1598-9992
Abstract
Hyponatremia is a commonly observed complication that is related to hypoalbuminemia and portal hypertension in patients with advanced liver cirrhosis. Hyponatremia in patients with liver cirrhosis is mostly dilutional hyponatremia and is defined when the serum sodium concentration is below 130 meq/L. The risk of complications increases significantly in cirrhotic patients with hyponatremia, which includes spontaneous bacterial peritonitis, hepatorenal syndrome, and hepatic encephalopathy. In addition, hyponatremia is associated with increased morbidity and mortality in patients with cirrhosis, and is an important prognostic factor before and after liver transplantation. The conventional therapies of hyponatremia are albumin infusion, fluid restriction and loop diuretics, but these are frequently ineffective. This review investigates the pathophysiology and various therapeutic modalities, including selective vasopressin receptor antagonists, for the management of hyponatremia in patients with liver cirrhosis.
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Jung, Young Kul
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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