Detailed Information

Cited 22 time in webofscience Cited 24 time in scopus
Metadata Downloads

Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort studyopen access

Authors
Seo, Yeon SeokJang, Byoung KukUm, Soon HoHwang, Jae SeokHan, Kwang-HyubKim, Sang GyuneLee, Kwan SikKim, Seung UpKim, Young SeokLee, Jung Il
Issue Date
Dec-2017
Publisher
IMPACT JOURNALS LLC
Keywords
hepatitis B; hepatocellular carcinoma; transient elastography; risk prediction; liver stiffness
Citation
ONCOTARGET, v.8, no.68, pp 113213 - 113224
Pages
12
Indexed
SCIE
SCOPUS
Journal Title
ONCOTARGET
Volume
8
Number
68
Start Page
113213
End Page
113224
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4327
DOI
10.18632/oncotarget.22375
ISSN
1949-2553
1949-2553
Abstract
Recently, modified REACH-B (mREACH-B) risk prediction model for hepatocellular carcinoma (HCC) development was proposed. We validated the accuracy of the mREACH-B model and compared its accuracy with those of other prediction models. Between 2006 and 2012, 1,241 patients with chronic hepatitis B (CHB) were recruited. All patients underwent transient elastography at enrollment. The median age of the study population (840 males, 401 females) was 49 years. The median PAGE-B, LSM-HCC, and mREACH-B values were 10, 10, and 8, respectively. Among patients without cirrhosis (n = 940, 75.7%), the median REACH-B value was 9. During the follow-up period (median 77.4 months), 66 (5.3%) and 83 (6.7%) patients developed HCC and liver-related events (LRE), respectively. Higher liver stiffness (LS) independently predicted HCC (hazard ratio [HR] = 1.047) and LRE development (HR = 1.047) (all P < 0.05). The mREACH-B significantly predicted HCC (AUC = 0.824 at 3-year and 0.750 at 5-year) and LRE development (AUC = 0.782 at 3-year and 0.739 at 5-year) (all P < 0.001) and it performed similarly or significantly better than the PAGE-B and LSM-HCC (AUC = 0.715-0.809 at 3-year and 0.719-0.742 at 5-year for HCC; AUC = 0.704-0.777 at 3-year and 0.721-0.735 at 5-year for LRE). Among patients without cirrhosis, mREACH-B predicted HCC (AUC = 0.803 vs. 0.654-0.816 at 3-year and 0.684 vs. 0.639-0.738 at 5-year) and LRE development (AUC = 0.734 vs. 0.619-0.789 at 3-year and 0.674 vs. 0.626-0.729 at 5-year) similarly to PAGE-B, REACH-B, and LSM-HCC. mREACH-B appropriately predicted HCC and LRE development in patients with CHB and showed similar or superior accuracy to those of PAGE-B, REACH-B, and LSM-HCC.
Files in This Item
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Seo, Yeon Seok photo

Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE