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Cited 5 time in webofscience Cited 7 time in scopus
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Impact of Gleason score on biochemical recurrence in patients with pT3aN0/Nx prostate cancer with positive surgical margins: a multicenter study from the Prostate Cancer Research Committee

Authors
Song, WanLee, Dong HyeonJeon, Hwang GyunJeong, Byong ChangSeo, Seong IlLee, Hyun MooChoi, Han YongKim, Jong WookLee, SangChulByun, Seok-SooJeong, Chang WookKwak, CheolCho, Jin SeonAhn, HanjongJeon, Seong Soo
Issue Date
Nov-2017
Publisher
SPRINGER
Keywords
Biochemical recurrence; Gleason score; Positive surgical margin; Prostate cancer; Prognostic factor
Citation
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, v.143, no.11, pp 2393 - 2400
Pages
8
Indexed
SCI
SCIE
SCOPUS
Journal Title
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume
143
Number
11
Start Page
2393
End Page
2400
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4486
DOI
10.1007/s00432-017-2502-7
ISSN
0171-5216
1432-1335
Abstract
Oncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients. A retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified. Kaplan-Meier survival analysis was used to illustrate BCR-free survival (BFS) and Cox proportional hazard models were applied to identify factors predicting BCR. During the mean follow-up period of 63.9 months, BCR was identified in 274 (34.5%) patients. The 5-year BFS was 56.6% in all patients. In multivariate analysis, pathologic GS was the only significant prognostic factor for BCR in patients with pT3aN0/Nx PCa with PSM (GS 6 vs. GS 7 (3 + 4), P = 0.047; vs. GS 7 (4 + 3), P = 0.007, and vs. GS 8-10, P < 0.001). When patients were stratified according to GS, 5-year BFS was 78.6% in GS 6, 66.2% in GS 7 (3 + 4), 51.1% in GS 7 (4 + 3) and 35.5% in GS 8-10. In patients with pT3aN0/Nx with PSM after RP, pathologic GS is the sole independent predictor for risk stratification of BCR. These findings might be used to determine the risk and timing of BCR and to help counsel patients regarding treatment strategy and prognosis of disease on an individual basis.
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