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Cited 287 time in webofscience Cited 321 time in scopus
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Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis

Authors
Wise, T.Radua, J.Via, E.Cardoner, N.Abe, O.Adams, T. M.Amico, F.Cheng, Y.Cole, J. H.de Azevedo Marques Perico, C.Dickstein, D. P.Farrow, T. F. D.Frodl, T.Wagner, G.Gotlib, I. H.Gruber, O.Ham, B. J.Job, D. E.Kempton, M. J.Kim, M. J.Koolschijn, P. C. M. P.Malhi, G. S.Mataix-Cols, D.McIntosh, A. M.Nugent, A. C.O'Brien, J. T.Pezzoli, S.Phillips, M. L.Sachdev, P. S.Salvadore, G.Selvaraj, S.Stanfield, A. C.Thomas, A. J.van Tol, M. J.van der Wee, N. J. A.Veltman, D. J.Young, A. H.Fu, C. H.Cleare, A. J.Arnone, D.
Issue Date
Oct-2017
Publisher
Nature Publishing Group
Citation
Molecular Psychiatry, v.22, no.10, pp.1455 - 1463
Indexed
SCIE
SCOPUS
Journal Title
Molecular Psychiatry
Volume
22
Number
10
Start Page
1455
End Page
1463
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4555
DOI
10.1038/mp.2016.72
ISSN
1359-4184
Abstract
Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.
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Ham, Byung Joo
Anam Hospital (Department of Psychiatry, Anam Hospital)
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