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Cited 7 time in webofscience Cited 8 time in scopus
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Higher Serum Levels of Osteoglycin Are Associated with All-Cause Mortality and Cardiovascular and Cerebrovascular Events in Patients with Advanced Chronic Kidney Diseaseopen access

Authors
Baek, Seon HaCha, Ran-huiKang, Shin WookPark, Cheol WheeCha, Dae RyongKim, Sung GyunYoon, Sun AeKim, SejoongHan, Sang YoubPark, Jung HwanChang, Jae HyunLim, Chun SooKim, Yon SuNa, Ki Young
Issue Date
Aug-2017
Publisher
TOHOKU UNIV MEDICAL PRESS
Keywords
all-cause mortality; biomarker; chronic kidney disease; diabetes mellitus; osteoglycin
Citation
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, v.242, no.4, pp 281 - 290
Pages
10
Indexed
SCI
SCIE
SCOPUS
Journal Title
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Volume
242
Number
4
Start Page
281
End Page
290
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4746
DOI
10.1620/tjem.242.281
ISSN
0040-8727
1349-3329
Abstract
Patients with chronic kidney disease (CKD) have markedly increased rates of major adverse cardiovascular and cerebrovascular events (MACCEs) and mortality. Therefore, identifying early bionnarkers predicting clinical outcomes in patients with CKD is critical. We aimed to determine whether osteoglycin, a basic component of the vascular extracellular matrix, was associated with MACCEs or all-cause mortality, using data from a prospective randomized controlled study, K-STAR (Krennezin STudy Against Renal disease progression in Korea: NCT 00860431). A total of 383 patients (mean age: 56.4 years, men/women = 252/131) with CKD stage 3 to 4 from the original trial were enrolled in the present study. We measured serum osteoglycin level and examined the impact of osteoglycin on clinical outcomes. The mean value of osteoglycin levels was 13.3 +/- 9.4 ng/mL (healthy control: 5.3 +/- 2.1 ng/mL). In multivariable analysis, lower levels of proteinuria and hemoglobin and higher levels of C-reactive protein were significantly associated with higher osteoglycin levels. Estimated glomerular filtration rate was not related to osteoglycin level. During a mean follow-up period of 56 months, 25 deaths, 61 MACCEs, and 76 composite outcomes (all-cause mortality or MACCEs) occurred. In the non-diabetic group, each 1-ng/mL increase in serum osteoglycin was associated with all-cause mortality and composite outcome (hazard ratio [HR] = 1.058, P = 0.031; HR = 1.041, P = 0.036). However, osteoglycin levels were not associated with mortality, MACCEs, or composite outcome in the diabetic group. Our results indicate that serum osteoglycin is a potential predictor of adverse outcomes in patients with CKD.
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Cha, Dae Ryong
Ansan Hospital (Department of Nephrology and Hypertension, Ansan Hospital)
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