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Cited 19 time in webofscience Cited 20 time in scopus
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Comparison of a split-dose bowel preparation with 2 liters of polyethylene glycol plus ascorbic acid and 1 liter of polyethylene glycol plus ascorbic acid and bisacodyl before colonoscopy

Authors
Kang, Seung HunJeen, Yoon TaeLee, Jae HyungYoo, In KyungLee, Jae MinKim, Seung HanChoi, Hyuk SoonKim, Eun SunKeum, BoraLee, Hong SikChun, Hoon JaiKim, Chang Duck
Issue Date
Aug-2017
Publisher
MOSBY-ELSEVIER
Keywords
1-L PEG/AB; 1-liter polyethylene glycol with ascorbic acid plus bisacodyl 10 mg; 2-L PEG/A; 2-liter polyethylene glycol with ascorbic acid; ABPS; Aronchick Bowel Preparation Scale; Asc; ascorbic acid; BBPS; Boston Bowel Preparation Scale; PEG; polyethylene glycol
Citation
GASTROINTESTINAL ENDOSCOPY, v.86, no.2, pp.343 - 348
Indexed
SCIE
SCOPUS
Journal Title
GASTROINTESTINAL ENDOSCOPY
Volume
86
Number
2
Start Page
343
End Page
348
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4781
DOI
10.1016/j.gie.2016.10.040
ISSN
0016-5107
Abstract
Background and Aims: Recently, a low-volume polyethylene glycol formulation containing ascorbic acid (PEG-Asc) has proven as safe and effective as traditional 4-L PEG solutions for colonoscopy preparation. However, currently available aqueous purgative formulations are poorly tolerated. The aim of this study was to compare a split-dose 2-L PEG-Asc formulation and a 1-L PEG-Asc formulation with bisacodyl (10 mg) to determine the quality of bowel cleansing and patient tolerability. Methods: A single-center, randomized, observer-blinded study was performed between May 2015 and September 2015. Two hundred outpatients referred for colonoscopy were prospectively enrolled and assigned to either the split-dose 2-L PEG-Asc group or the 1-L PEG-Asc with bisacodyl 10-mg group. The Boston Bowel Preparation Scale (BBPS) and Aronchick Bowel Preparation Scale (ABPS) were used to evaluate bowel cleansing. The tolerability of the regimens and satisfaction of patients was determined based on a questionnaire. Results: Two hundred patients received either 2-L PEG-Asc or 1-L PEG-Asc with bisacodyl. Regarding colon cleansing outcome (BBPS and ABPS), the 1-L PEG-Asc with bisacodyl group showed similar but non-inferior results compared with the 2-L PEG-Asc group on both BBPS (6.92 +/- 1.63 vs 6.57 +/- 1.37; P = .103) and ABPS (96% vs 95%; P = 1.000) scales. Tolerability was similar for both 1-L PEG-Asc with bisacodyl and 2-L PEG-Asc. Conclusions: 1-L PEG-Asc is a suitable alternative to low-volume bowel preparation for colonoscopy. Our study showed that the 1-L PEG-Asc plus bisacodyl preparation has comparable tolerability and results in adequate colon cleansing. Bowel preparation with bisacodyl and 1-L PEG-Asc is a suitable alternative to low-volume bowel preparation for colonoscopy.
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