Detailed Information

Cited 3 time in webofscience Cited 3 time in scopus
Metadata Downloads

The number of metabolic features as a significant prognostic factor in patients with metastatic renal cell carcinoma

Authors
Yuk, Hyeong DongHwang, Eu ChangPark, Jae YoungJeong, Chang WookSong, CherynSeo, Seong IlByun, Seok-SooKwak, CheolHong, Sung-HooKang, MinyongChung, JinsooLee, Hakmin
Issue Date
Apr-2020
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.10, no.1
Indexed
SCIE
SCOPUS
Journal Title
SCIENTIFIC REPORTS
Volume
10
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/49357
DOI
10.1038/s41598-020-63816-9
ISSN
2045-2322
Abstract
The effect of metabolic characteristics on the prognosis of patients with metastatic renal cell carcinoma remains controversial. We investigated the associations between metabolic features of each individual and disease prognosis in patients with metastatic renal cell carcinoma. Data of 1,584 patients with metastatic renal cell carcinoma from a multi-institutional database were retrospectively analyzed. The entire cohort was stratified into three subgroups according to how many patients had abnormal metabolic features (hypertension, diabetes mellitus, and low body mass index). The Kaplan-Meier and Cox proportional analyses were performed to investigate the associations between abnormal metabolic features and disease prognosis. mThere were 465 subjects without any metabolic features, 995 with one or two, and 124 with three. When the survival outcomes were compared according to the number of metabolic features, patients with higher numbers of metabolic features had significantly shorter overall and cancer-specific survival than those with fewer metabolic features (all p values <0.05). The multivariate Cox analysis showed that the number of metabolic features was an independent predictor for shorter cancer-specific and overall survival (all p values < 0.05). When performing subgroup analysis according to the cellular type, significant results were only obtained among the clear cell subtype subgroup, with the association not being significant in the non-clear cell subtype cohort. Patients with more metabolic features had significantly worse survival outcomes than those with fewer metabolic features. However, the association was only statistically significant in patients with clear cell-type metastatic renal cell carcinoma.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Urology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Jae Young photo

Park, Jae Young
Ansan Hospital (Department of Urology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE