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Cited 6 time in webofscience Cited 8 time in scopus
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Expression of Hepatocyte Hepatitis B Core Antigen and Hepatitis B Surface Antigen as a Marker in the Management of Chronic Hepatitis B Patients

Authors
Yim, Sun YoungKim, Tae HyungJun, Suh SangKim, Eun SunKeum, BoraSeo, Yeon SeokYim, Hyung JoonJeen, Yoon TaeChun, Hoon JaiLee, Hong SikUm, Soon HoKim, Chang DuckWon, Nam HeeRyu, Ho Sang
Issue Date
May-2017
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Hepatitis B, chronic; Hepatitis B core antigens; Hepatitis B surface antigens; Histologic activity index
Citation
GUT AND LIVER, v.11, no.3, pp.417 - 425
Indexed
SCIE
SCOPUS
KCI
Journal Title
GUT AND LIVER
Volume
11
Number
3
Start Page
417
End Page
425
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5063
DOI
10.5009/gnl16148
ISSN
1976-2283
Abstract
Background/Aims: We aimed to clarify the association of hepatitis B surface antigen (HBsAg)/hepatitis B core antigen (HBcAg) with the disease status and treatment response in patients with chronic hepatitis B (CHB). Methods: We investigated 171 biopsy-proven entecavir-treated CHB patients (109 hepatitis B e antigen [HBeAg]-positive, 62 HBeAg-negative). HBcAg expression was positive when >= 10% of hepatocytes stained, and classified into nuclear, mixed, and cytoplasmic patterns. HBsAg expressions were intracytoplasmic (diffuse, globular, and submembranous) and membranous. The histologic activity index (HAI) and fibrosis stage followed Ishak system. Results: In HBeAg-positive patients, older age, increased HAI score, advanced fibrosis, and reduced viral load were observed when HBcAg expression shifted from nucleus to cytoplasm in HBcAg-positive patients, and HBsAg expression from non-submembranous to submembranous in HBcAg-negative patients (all, p<0.05). In HBeAg-negative patients, only intracytoplasmic HBsAg expression patterns had clinical relevance with decreased ALT levels and viremia. In HBeAg-positive patients without favorable predictors of virologic response, negative HBcAg and membranous HBsAg expression predicted greater virologic response (both, p<0.05). The probability of HBeAg seroclearance was higher in patients with increased HAI or lacking HBcAg expression (both, p<0.05). Higher serum HBsAg levels and hepatocyte HBcAg positivity were associated with reduced serum HBsAg during first and post-first year treatment, respectively (both, p<0.05). Conclusions: Hepatocyte HBcAg/HBsAg expression is a good marker for disease status and predicting treatment response.
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5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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