Detailed Information

Cited 18 time in webofscience Cited 19 time in scopus
Metadata Downloads

The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2

Authors
Jeong, JaekwangVanHouten, Joshua N.Kim, WonnamDann, PamelaSullivan, CatherineChoi, JungminSneddon, W. BruceFriedman, Peter A.Wysolmerski, John J.
Issue Date
Apr-2017
Publisher
American Society for Biochemistry and Molecular Biology Inc.
Citation
Journal of Biological Chemistry, v.292, no.16, pp 6555 - 6568
Pages
14
Indexed
SCI
SCIE
SCOPUS
Journal Title
Journal of Biological Chemistry
Volume
292
Number
16
Start Page
6555
End Page
6568
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5094
DOI
10.1074/jbc.M116.770883
ISSN
0021-9258
1083-351X
Abstract
Weexamined whether the scaffolding protein sodium-hydrogen exchanger regulatory factor 1 (NHERF1) interacts with the calcium pump PMCA2 and the tyrosine kinase receptor ErbB2/ HER2 in normal mammary epithelial cells and breast cancer cells. NHERF1 interacts with the PDZ-binding motif in PMCA2 in both normal and malignant breast cells. NHERF1 expression is increased in HER2-positive breast cancers and correlates with HER2-positive status in human ductal carcinoma in situ (DCIS) lesions and invasive breast cancers as well as with increased mortality in patients. NHERF1 is part of a multiprotein complex that includes PMCA2, HSP90, and HER2 within specific actinrich and lipid raft-rich membrane signaling domains. Knocking down NHERF1 reduces PMCA2 and HER2 expression, inhibits HER2 signaling, dissociates HER2 from HSP90, and causes the internalization, ubiquitination, and degradation of HER2. These results demonstrate that NHERF1 acts with PMCA2 to regulate HER2 signaling and membrane retention in breast cancers.
Files in This Item
There are no files associated with this item.
Appears in
Collections
3. Graduate School > Biomedical Research Center > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Jungmin photo

Choi, Jungmin
College of Medicine (Department of Medical Informatics)
Read more

Altmetrics

Total Views & Downloads

BROWSE