Sarcopenia as a Predictor of Prognosis in Early Stage Ovarian Cancer
- Authors
- Chae Su Hyun; Lee Chulmin; Yoon Sang-Hee; Shim Seung-Hyuk; Lee Sun Joo; Kim Soo-Nyung; Chung Sochung; Lee Ji Young
- Issue Date
- 4-Jan-2021
- Publisher
- 대한의학회
- Keywords
- Early Stage Ovarian Cancer; Sarcopenia; Overall Survival; Prognostic Factor
- Citation
- Journal of Korean Medical Science, v.36, no.1, pp 1 - 12
- Pages
- 12
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Korean Medical Science
- Volume
- 36
- Number
- 1
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51208
- DOI
- 10.3346/jkms.2021.36.e2
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: To identify sarcopenia as a predictive prognostic factor of ovarian cancer in terms of survival outcome in patients with early-stage ovarian cancer.
Methods: Data of Konkuk University Medical Center from March 2002 to December 2017 were reviewed retrospectively. Eighty-two patients who underwent surgery due to early-stage (International Federation of Gynecology and Obstetrics stage I/II) ovarian cancer and had computed tomography (CT) images taken at the initial diagnosis were included. The initial CT scan images were analyzed with SliceOmatic software (TomoVision). A sarcopenia cutoff value was defined as a skeletal muscle index of ≤ 38.7 cm2 /m2 . Overall survival (OS) times were compared according to the existence of sarcopenia, and subgroup analyses were performed.
Results: A Kaplan-Meier analysis showed a significant survival disadvantage for patients with early-stage ovarian cancer when they had sarcopenia (P < 0.001; log-rank test). Sarcopenia remained a significant prognostic factor for OS in early-stage ovarian cancer, in a Cox proportional hazards model regression analysis (HR, 21.9; 95% CI, 2.0–199.9; P = 0.006).
Conclusion: This study demonstrated that sarcopenia was predictive of OS in patients with early-stage ovarian cancer. Further prospective studies with a larger number of patients are warranted to determine the extent to which sarcopenia can be used as a prognostic factor in ovarian cancer.
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Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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