Detailed Information

Cited 6 time in webofscience Cited 3 time in scopus
Metadata Downloads

Surgery versus external beam radiotherapy for hepatocellular carcinoma involving the inferior vena cava or right atrium: A systematic review and meta-analysis

Authors
Lee, Han AhPark, SunminSeo, Yeon SeokYoon, Won SupShin, In-SooRim, Chai Hong
Issue Date
Dec-2021
Publisher
Springer Verlag
Keywords
hepatocellular carcinoma; inferior vena cava; meta-analysis; radiotherapy; surgery
Citation
Journal of Hepato-Biliary-Pancreatic Sciences, v.28, no.12, pp.1031 - 1046
Indexed
SCIE
SCOPUS
Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
Volume
28
Number
12
Start Page
1031
End Page
1046
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51647
DOI
10.1002/jhbp.865
ISSN
1868-6974
Abstract
We investigated the efficacy and safety of surgery and external beam radiotherapy (EBRT), in patients with hepatocellular carcinoma (HCC) involving the inferior vena cava (IVC) and/or right atrium (RA) through a comparative meta-analysis. A systematic search of PubMed, MEDLINE, EMBASE, and the Cochrane library was performed for entries until July 2020. Eighteen studies with 22 cohorts were included, encompassing 755 patients. The pooled median overall survival (OS) and 1- and 2-year OS rates were 14.2 months, 55.6%, and 27.4%, respectively. The pooled median OS in the surgery and EBRT arms were 15.3 and 11.7 months, respectively. The pooled 1-year OS rate in the surgery arm was significantly higher than that in the EBRT arm (62.4%, 95% CI: 53.8%-70.3% vs 48.8%, 95% CI: 40.9-56.8, respectively; P = .023), while the 2-year OS rates were similar (27.5%, 95% CI: 19.7%-37.1% vs 26.9%, 95% CI: 20.7-34.2, respectively; P = .913). In the surgical arm, the perioperative mortality and grade >= 3 complication rates were 0%-7.6% and 3.9%-67%, respectively. Grade >= 3 complications and radiation-induced liver disease were rarely observed in the EBRT arm. Surgery could be an effective local modality for achieving the best survival rate, though it requires efforts to minimize morbidities and careful patient selection. EBRT, as a noninvasive modality, is a valid palliative option, especially for high-risk patients with a shorter life expectancy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Radiation Oncology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Rim, Chai Hong photo

Rim, Chai Hong
Ansan Hospital (Department of Radiation Oncology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE