韓國産 植物凝集素 Vicia pallida Turcz.의 凝集活性에 關한 硏究

Abstract

After Stillmark's report on agglutination of human and animal red blood cell (RBC) by plant extracts, numerous studies on phytagglutinin was performed. Phytagglutinin was divided into species-specific phytagglutinin, type-specific phytagglutinin and pan-phytagglutinin. Therefore, the author performed agglutination test with human RBC and with ficinated RBC, and agglutinating inhibition test with human saliva and various sugar solution, by using extract of Korean native Vicia pallida. The results could be summarized as follows; 1) Human RBC was divided into agglutinating group and not agglutinating group by extracts of Vicia pallida, and it was designated the former as Vp (+) type and the latter as Vp(-) type. The distribution of Vp(+) type was 78.80% and Vp(-) type was 21.20% in 1,118 of Korean blood samples. 2) There were no differences in the distribution of Vp (+) and Vp (-) type frequencies between male and female, among ABO blood groups and MN blood groups. 3) No appreciable difference was noted in the distribution of Vp group among tested patient groups. 4) Agglutinating activity of ficinated RBCs with extracts of Vicia pallida was decreased. 5) Agglutinating activity of extracts of Vicia pallida was not inhibited by human saliva. 6) Agglutinating activity of extracts of Vicia pallida were inhibited by dextrose, D-mannose, and lactose.