CCl₄의 肝臟毒作用에 미치는 交感神經遮斷藥들의 影響

Abstract

In this paper, the influences of adrenergic blockades; phenoxybenzamine, propranolol and hexamethonium on the changes induced by carbon tetrachloride(CCl₄) of hepatic total lipid, glycogen, and lipid peroxide contents and serum lactic dehydrogenase activity were investigated in male mice. The results obtained were summarized as follows; 1. Hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were not significantly changed by phenoxybenzamine(10㎎/㎏), propranolol(1㎎/㎏), and hexamethonium(10㎎/㎏), but hepatic glycogen content was significantly decreased by them. 2. Hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were markedly increased by CCl₄ but hepatic glycogen content was decreased. 3. The increase of hepatic total lipid induced by CCl₄ was not affected by the phenoxybenzamine pretreatment and moderately inhibited by the propranolol, but significantly inhibited by the hexamethonium pretreatment. 4. The decrease of hepatic glycogen content induced by CCl₄ was not affected by the pretreatment of phenoxybenzamine, propranolol or hexamethonium. 5. The increase of hepatic lipid peroxide induced by CCl₄ was not affected by the phenoxybenzamine or propranolol pretreatment, but slightly inhibited by the pretreatment of hexamethonium. 6. The increase of serum lactic dehydrogenase activity induced by CCl₄ was not affected by the pretreatment of hexamethonium, but the increase was slightly inhibited by the phenoxybenzamine or propranolol pretreatment.