人蔘脂溶牲 成分이 四鹽化炭素 投與 白鼠의 蛋白質代謝에 미치는 影響

Abstract

In order to observe a part of the effect of Ginseng fat soluble components (Gx) on the protein metabolism under CCI₄ poisoning, 192 male and female albino rats were taken as subjects which were divided into 6 experimental groups i.e. control grop; CCI₄ group which were observed after CCI₄ and been administered only one time; Gx group which were observed administering Ginseng one time daily; CCI₄+Gx group which were observed administering Ginseng one time daily after CCI₄ had been administered, Gx+CCI₄ group to which CCI₄ was administered only on time after Ginseng had been administered 6 times; and Gx_CCI₄+Gx group to which Ginseng was administered one time daily after CCI₄ had been administered following a 6th time administration of Ginseng. Programed administrations of Ginseng or CCI₄ were given to each corresponding groups at several periods i.e. 1,2,4,6 and 8 days after the intial administration of given doses, changes of total protein, albumin, globulin, urea nitrogen, transaminase (GOT) of serum and total nitrogen observed at each period were measured and the results obtained are as follows: 1. Gx administration was found to have the ability to decrease the elevated SGOT activity resulting from administration of CCI₄ and induce rapid recrovery from such an elevated level and the extent of such a dereasing action was greatest in Gx+CCI₄+Gx group, than Gx+CCI₄ group, and the least in CCI₄+Gx group. 2. Gx+CCI₄+Gx group showed nearly no change in serum albumin level, and being in second place, Gx administering groups (CCI₄+Gx group, Gx+CCI₄ group) showed small change. 3. Gx administering groups showed more increase in globulin level at 1-2 day period than the CCI₄ group and during the same period A/G ratio was found inverted. 4. Total nitrogen amount in the liver was remarkably decreased in Gx administering groups at 2 day period. 5. Urea nitrogen was increased in CCI₄ group at 2 day period, whereas Gx administering groups showed decreases. 6. Great changes in electrophoresis fractions were found in α₁-and r-globulin fractions at 1-2 day period. For more detail a. α₁-globulin; Gx administering groups showed lower increases than the CCI₄ group at 2 day period. b. r-globulin; Gx_CCI₄ group and CCI₄+Gx group showed more increases than the CCI₄ group at 1-2 day period. 7. α₂-globulin, revealing characteristic pattern, was increased to the same extent in all the Gx administerings groups during Gx administering period, thus Gx was estimated to increase the α₂-globulin component.