Cushing's syndrome due to primary pigmented nodular adrenocortical disease--a case report reviews of the literature.
- Authors
- Choi K.M.; Seu J.H.; Kim Y.H.; Lee E.J.; Kim S.J.; Baik S.H.; Choi D.S.
- Issue Date
- Jan-1995
- Citation
- The Korean journal of internal medicine, v.10, no.1, pp 68 - 72
- Pages
- 5
- Indexed
- SCOPUS
- Journal Title
- The Korean journal of internal medicine
- Volume
- 10
- Number
- 1
- Start Page
- 68
- End Page
- 72
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52529
- DOI
- 10.3904/kjim.1995.10.1.68.
- ISSN
- 1226-3303
2005-6648
- Abstract
- Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Cushing's syndrome in infants, children and young adults. It is characterized by non-adrenocorticotropic hormone-dependent hypersecretion of cortisol by multiple, pigmented nodules of hyperplastic adrenocortical cells. Biochemically, PPNAD is characterized by elevated levels of plasma and urinary cortisol that are not suppressed by high doses of dexamethasone (8mg/d for 2 days). Pathologically, the adrenal glands contain multiple dark brown or black nodules and the intervening cortical tissue is atrophic. Recognition of this diagnosis, although rare, is important, as bilateral adrenalectomy is the treatment of choice. We experienced a case of Cushing's syndrome due to primary pigmented nodular adrenocortical disease and report it with reviews of the literature.
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- Appears in
Collections - 2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Cardiology > 1. Journal Articles
- 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
- 2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
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