Regional amyloid burden and lacune in pure subcortical vascular cognitive impairment
- Authors
- Hong, Yun Jeong; Kim, Chan-Mi; Kim, Ji Eun; Roh, Jee Hoon; Kim, Jae Seung; Seo, Sang Won; Na, Duk L.; Lee, Jae-Hong
- Issue Date
- Jul-2017
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Vascular cognitive impairment; Pittsburgh compound B; Amyloid; Subcortical vascular mild cognitive impairment; Subcortical ischemic vascular dementia; Cerebral small vessel disease
- Citation
- NEUROBIOLOGY OF AGING, v.55, pp 20 - 26
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- NEUROBIOLOGY OF AGING
- Volume
- 55
- Start Page
- 20
- End Page
- 26
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52848
- DOI
- 10.1016/j.neurobiolaging.2017.03.010
- ISSN
- 0197-4580
1558-1497
- Abstract
- We investigated the amyloid and vascular burden in Pittsburgh compound B (PiB)-negative subcortical vascular mild cognitive impairment (svMCI) and PiB-negative subcortical ischemic vascular dementia (SIVD) to elucidate the potential roles of amyloid deposition and small vessel disease (SVD). Thirty-eight svMCI patients and 42 SIVD patients were enrolled. The regional PiB uptake values and SVD markers were obtained and compared between groups. Additionally, correlations among amyloid burden, SVD, and cognition were made. Patients with PiB-negative SIVD showed more amyloid deposition than those with PiB-negative svMCI, particularly in the cuneus, lingual gyrus, supramarginal, and angular gyri. Despite subthreshold levels for amyloid deposition, our findings showed a marked regional difference in amyloid uptake between svMCI and SIVD, particularly in posteriorly located brain areas. However, lacune, a proxy for vascular burden, showed a broader association with cognition and had more impacts on developing dementia than amyloid burden. The topographical pattern of amyloid deposition and its impact on clinical status in pure subcortical vascular cognitive impairment were different from those in Alzheimer's disease. (C) 2017 Elsevier Inc. All rights reserved.
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