Overcome the barriers of the skin: exosome therapy
- Authors
- Yang, Gi Hoon; Lee, Yoon Bum; Kang, Donggu; Choi, Eunjeong; Nam, Yoonju; Lee, Kyoung Ho; You, Hi-Jin; Kang, Hyo Jin; An, Sang Hyun; Jeon, Hojun
- Issue Date
- 3-Jul-2021
- Publisher
- SPRINGERNATURE
- Keywords
- Exosomes; Biomarker; Skin defects; Skin treatment
- Citation
- BIOMATERIALS RESEARCH, v.25, no.1, pp 230 - 242
- Pages
- 13
- Indexed
- KCI
- Journal Title
- BIOMATERIALS RESEARCH
- Volume
- 25
- Number
- 1
- Start Page
- 230
- End Page
- 242
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53948
- DOI
- 10.1186/s40824-021-00224-8
- ISSN
- 1226-4601
2055-7124
- Abstract
- Exosomes are nano-sized cargos with a lipid bilayer structure carrying diverse biomolecules including lipids, proteins, and nucleic acids. These small vesicles are secreted by most types of cells to communicate with each other. Since exosomes circulate through bodily fluids, they can transfer information not only to local cells but also to remote cells. Therefore, exosomes are considered potential biomarkers for various treatments. Recently, studies have shown the efficacy of exosomes in skin defects such as aging, atopic dermatitis, and wounds. Also, exosomes are being studied to be used as ingredients in commercialized skin treatment products. In this review, we discussed the need for exosomes in skin therapy together with the current challenges. Moreover, the functional roles of exosomes in terms of skin treatment and regeneration are overviewed. Finally, we highlighted the major limitations and the future perspective in exosome engineering.
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- Appears in
Collections - 4. Research institute > Healthcare Readiness Institute for Unified Korea > 1. Journal Articles
- 2. Clinical Science > Department of Plastic and Reconstructive Surgery > 1. Journal Articles
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