Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways
- Authors
- Ha, Young-min; Chun, Su-hyun; Hong, Seung Taek; Koo, Yoonchang; Cho, Heedon; Lee, Kwangwon
- Issue Date
- Sep-2013
- Publisher
- Elsevier BV
- Keywords
- Galactomannan; Immune-modulating effect; Lysozyme; Maillard reaction
- Citation
- International Journal of Biological Macromolecules, v.60, pp 399 - 404
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- International Journal of Biological Macromolecules
- Volume
- 60
- Start Page
- 399
- End Page
- 404
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54020
- DOI
- 10.1016/j.ijbiomac.2013.06.007
- ISSN
- 0141-8130
1879-0003
- Abstract
- We studied the immune-modulating effect of Maillard-type lysozyme-galactomannan conjugate (LGC). LGC significantly induced nitric oxide, and expressions of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-8 on the murine macrophage Raw 264.7 cell line. In the mechanism of LGC, while extracellular signal-regulated kinase (ERK) was important for the induction of TNF-α, IL-1β and IL-8, the phosphorylation of C-Jun NH2-termianl kinase (JNK) contributed to the induction of TNF-α and IL-1β to a greater degree. These cytokines were less sensitive to the inhibition of p38. Nuclear factor (NF)-κB was involved in the induction of TNF-α and IL-1β. These data indicate that LGC has immune-modulating effects via JNK, ERK and NF-κB pathways, and that LGC may contribute to host immune defense. © 2013 Elsevier B.V.
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Collections - 4. Research institute > Institute of Gastrointestinal Medical Instrument Research > 1. Journal Articles
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