Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage
- Kim, Seongmin; Kim, Sung-Woo; Han, Soo-Jin; Lee, Sanghoon; Park, Hyun-Tae; Song, Jae-Yun; Kim, Tak
- Issue Date
- chemotherapy; radiotherapy; gonadotoxicity; fertility preservation; embryo cryopreservation; oocyte cryopreservation; ovarian tissue cryopreservation; oocyte in vitro maturation; ovarian suppression; oncofertility
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.14
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fertility preservation is an emerging discipline, which is of substantial clinical value in the care of young patients with cancer. Chemotherapy and radiation may induce ovarian damage in prepubertal girls and young women. Although many studies have explored the mechanisms implicated in ovarian toxicity during cancer treatment, its molecular pathophysiology is not fully understood. Chemotherapy may accelerate follicular apoptosis and follicle reservoir utilization and damage the ovarian stroma via multiple molecular reactions. Oxidative stress and the radiosensitivity of oocytes are the main causes of gonadal damage after radiation treatment. Fertility preservation options can be differentiated by patient age, desire for conception, treatment regimen, socioeconomic status, and treatment duration. This review will help highlight the importance of multidisciplinary oncofertility strategies for providing high-quality care to young female cancer patients.
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- 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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