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Cited 2 time in webofscience Cited 2 time in scopus
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Prognostic factors for overall survival in patients with clear cell metastatic renal cell carcinoma Model development and external validation with Memorial Sloan Kettering Cancer Center model and the international metastatic renal cell carcinoma database consortium model

Authors
Shin, DongrulJeong, Chang WookSong, CherynKang, MinyongSeo, Seong IlKim, Jung KwonLee, HakminChung, JinsooHong, Sung-HooHwang, Eu ChangKwak, CheolPark, Jae Young
Issue Date
6-Aug-2021
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
biomarkers; kidney neoplasms; prognostic factors; renal cell carcinoma; survival rate
Citation
MEDICINE, v.100, no.31, pp E26826
Indexed
SCIE
SCOPUS
Journal Title
MEDICINE
Volume
100
Number
31
Start Page
E26826
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54123
DOI
10.1097/MD.0000000000026826
ISSN
0025-7974
1536-5964
Abstract
To develop a new prognostic model for the overall survival of patients with clear cell metastatic renal cell carcinoma (mRCC) using Korean Renal Cancer Study Group (KRoCS) database and compared it with 2 renowned prognostic models: the Memorial Sloan Kettering Cancer Center (MSKCC) and the international metastatic renal cell carcinoma database consortium (IMDC) models. Data of 790 patients diagnosed with mRCC and receiving targeted therapy as their first-line treatment were pooled to this study. Data from 4 hospitals (n = 619) were used to develop the new model and those from other 5 hospitals (n = 171) were used for external validation. After detecting prognostic factors in multivariable Cox proportional-hazards regression analysis, patients were classified into 3 risk groups, favorable (0), intermediate (1-2), and poor (3 and more) by the number of prognostic factors. Seven variables such as more than 2 metastasis sites, no prior nephrectomy, Eastern Cooperative Oncology Group performance status >= 2, low hemoglobin, high serum corrected calcium, high neutrophil, high serum alkaline phosphatase were identified as prognostic factors for poor overall survival. Also, risk groups were categorized into 3 groups; median overall survival was 61.1 months in favorable, 26.5 months in intermediate, and 6.8 months in poor group. KRoCS ranked the first in all 3 statistical parameters including akaike information criterion (AIC), concordance index and generalized R-2 among other prognostic models. We developed the KRoCS model and validated it externally with demonstrating its superiority over MSKCC and IMDC models. The KRoCS model can provide useful information for counseling patients with clear cell mRCC regarding life-expectancy.
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