Ramucirumab plus paclitaxel as second-line treatment in patients with advanced gastric or gastroesophageal junction adenocarcinoma: a nationwide real-world outcomes in Korea study (KCSG-ST19-16)
- Authors
- Han, Hye Sook; Kim, Bum Jun; Jee, Hee-Jung; Ryu, Min-Hee; Park, Se Hoon; Rha, Sun Young; Kim, Jong Gwang; Bae, Woo Kyun; Lee, Keun-Wook; Oh, Do-Youn; Kim, In-Ho; Sym, Sun Jin; Oh, So Yeon; Kim, Hyeong Su; Byun, Ji-Hye; Kim, Dong Sook; Suh, Young Ju; An, Hyonggin; Zang, Dae Young
- Issue Date
- Sep-2021
- Publisher
- SAGE Publications
- Keywords
- gastric cancer; paclitaxel; ramucirumab; real-world data
- Citation
- Therapeutic Advances in Medical Oncology, v.13
- Indexed
- SCIE
SCOPUS
- Journal Title
- Therapeutic Advances in Medical Oncology
- Volume
- 13
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54444
- DOI
- 10.1177/17588359211042812
- ISSN
- 1758-8340
1758-8359
- Abstract
- Background: Ramucirumab as monotherapy or in combination with paclitaxel is a second-line treatment option recommended for patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, real-world data from large study cohorts focused on ramucirumab plus paclitaxel in gastric cancer are limited. Methods: The study population comprised all patients with gastric or GEJ cancer who received ramucirumab plus paclitaxel in South Korea between 1 May 2018 and 31 December 2018. We included patients with advanced gastric or GEJ adenocarcinoma and disease progression after first-line platinum and fluoropyrimidine-containing combination chemotherapy. Results: In total, 1063 patients were included in the present study. The objective response rate and disease control rate were 15.1% and 57.7%, respectively. The median progression-free survival was 4.03months (95% confidence interval, 3.80-4.27) and the median overall survival was 10.03months (95% confidence interval, 9.33-10.73). Grade 3 or higher treatment-related adverse events with incidence of 5% were neutropenia (35.1%) and anemia (10.5%). Based on multivariable analysis, overall survival was negatively associated with Eastern Cooperative Oncology Group performance status 2, weight loss 10% in the previous 3months, GEJ of primary tumor, poor or unknown histologic grade, number of metastatic sites 3, presence of peritoneal metastasis, no prior gastrectomy, and time to second-line since first-line treatment <6months. Conclusion: Our large-scale, nationwide, real-world data analysis of an unselected real-world population adds evidence for the efficacy and safety of second-line ramucirumab plus paclitaxel in patients with locally advanced unresectable or metastatic gastric or GEJ adenocarcinoma.
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- Appears in
Collections - 1. Basic Science > Department of Biostatistics > 1. Journal Articles
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