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Prokinetic effects of diatrizoate meglumine (Gastrografin (R)) in a zebrafish for opioid-induced constipation model

Authors
Kim, DongwooKoun, SoonilKim, Seung YoungHa, Young RanChoe, Jung WanJung, Sung WooHyun, Jong JinJung, Young KulKoo, Ja SeolYim, Hyung JoonLee, Sang Woo
Issue Date
3-Sep-2021
Publisher
한국통합생물학회
Keywords
Zebrafish; constipation; gastrografin
Citation
Animal Cells and Systems, v.25, no.5, pp.264 - 271
Indexed
SCIE
SCOPUS
KCI
Journal Title
Animal Cells and Systems
Volume
25
Number
5
Start Page
264
End Page
271
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54643
DOI
10.1080/19768354.2021.1991472
ISSN
1976-8354
Abstract
Constipation is a common disease that reduces life quality. Drugs of various mechanisms are being developed to resolve this affliction. Intestinal motility can be easily monitored in zebrafish, and so we selected this organism to develop a constipation model to measure drug-induced prokinetic effects. In this study, intestinal motility was monitored in zebrafish by tracking intestinal transit using fluorescence, after which an opioid-induced constipation model was established using loperamide. We then evaluated the prokinetic effect of diatrizoate meglumine (Gastrografin (R)), which has been empirically used to treat post-operative ileus or adhesive small bowel obstructions. Diatrizoate meglumine was effective in promoting bowel movements in an opioid-induced zebrafish constipation model and its prokinetic effect was associated with an increased expression of interstitial cells of Cajal (ICC) markers. Therefore, the loperamide-induced zebrafish constipation model developed herein is a promising tool to evaluate novel constipation therapies.
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4. Research institute > Zebrafish Translational Medical Research Center > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Koo, Ja Seol
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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