Clinical impact of left atrial enlargement in Korean patients with atrial fibrillationopen access
- Authors
- Cho, Min Soo; Park, Hyoung-Seob; Cha, Myung-Jin; Lee, So-Ryoung; Park, Jin-Kyu; Kim, Tae-Hoon; Lee, Jung Myung; Park, Junbeom; Park, Hyung Wook; Kang, Ki-Woon; Shim, Jaemin; Uhm, Jae-Sun; Kim, Jin-Bae; Kim, Changsoo; Lee, Young Soo; Choi, Eue-Keun; Joung, Boyoung; Kim, Jun
- Issue Date
- Dec-2021
- Publisher
- Nature Publishing Group
- Citation
- Scientific Reports, v.11, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 11
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54953
- DOI
- 10.1038/s41598-021-03266-z
- ISSN
- 2045-2322
- Abstract
- We sought to evaluate the clinical implication of LAE based on left atrial anterior-posterior (LA AP) dimension or LA volume index (LAVI) in Korean patients with atrial fibrillation (AF). We enrolled 8159 AF patients from the CODE-AF registry. The primary outcome was rate of stroke or systemic embolism (SSE). The prevalence of mild, moderate, and severe LAE by LA AP dimension was 30.6%, 18.5%, and 21.4%, and by LAVI (available in 5808 patients) was 15.7%, 12.5% and 37.8%, respectively. Compared with no or mild LAE, patients with significant LAE (moderate to severe LAE, n = 3258, 39.9%) were associated with a higher rate of SSE (2.5% vs. 1.4%, P = 0.001). Multivariable analysis suggested presence of significant LAE by LA AP dimension was associated with a higher risk of SSE in the overall population (HR 1.57, 95% CI: 1.14-2.17, P = 0.005) and in patients using anticoagulants (n = 5836, HR 1.79, 95% CI: 1.23-2.63, P = 0.002). Patients with significant LAE by LAVI were also at higher risk of SSE (HR 1.58, 95% CI: 1.09-2.29, P = 0.017). In conclusion, significant LAE by LA dimension or LAVI was present in 39.9% and 50.2% of AF patients, respectively, and was associated with a higher rate of SSE.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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