Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology
- Authors
- McCarthy, Michael J.; Gottlieb, John F.; Gonzalez, Robert; McClung, Colleen A.; Alloy, Lauren B.; Cain, Sean; Dulcis, Davide; Etain, Bruno; Frey, Benicio N.; Garbazza, Corrado; Ketchesin, Kyle D.; Landgraf, Dominic; Lee, Heon-Jeong; Marie-Claire, Cynthia; Nusslock, Robin; Porcu, Alessandra; Porter, Richard; Ritter, Philipp; Scott, Jan; Smith, Daniel; Swartz, Holly A.; Murray, Greg
- Issue Date
- May-2022
- Publisher
- WILEY
- Keywords
- actigraphy; animal models; biomarker; chronobiology; circadian; clock gene; levels of analysis; light; lithium; sleep
- Citation
- Bipolar Disorders, v.24, no.3, pp 232 - 263
- Pages
- 32
- Indexed
- SCOPUS
- Journal Title
- Bipolar Disorders
- Volume
- 24
- Number
- 3
- Start Page
- 232
- End Page
- 263
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55021
- DOI
- 10.1111/bdi.13165
- ISSN
- 1398-5647
1399-5618
- Abstract
- Aim
Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, circadian rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD.
Method
Drawing upon expertise in animal models, biomarkers, physiology, and behavior, CTF analyzed the relevant cross-disciplinary literature to precisely frame the discussion around circadian rhythm disruption in BD, highlight key findings, and for the first time integrate findings across levels of analysis to develop an internally consistent, coherent theoretical framework.
Results
Evidence from multiple sources implicates the circadian system in mood regulation, with corresponding associations with BD diagnoses and mood-related traits reported across genetic, cellular, physiological, and behavioral domains. However, circadian disruption does not appear to be specific to BD and is present across a variety of high-risk, prodromal, and syndromic psychiatric disorders. Substantial variability and ambiguity among the definitions, concepts and assumptions underlying the research have limited replication and the emergence of consensus findings.
Conclusions
Future research in circadian rhythms and its role in BD is warranted. Well-powered studies that carefully define associations between BD-related and chronobiologically-related constructs, and integrate across levels of analysis will be most illuminating.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.