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Cited 11 time in webofscience Cited 11 time in scopus
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MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells

Authors
Jeong, JaekwangShin, Jae HunLi, WenxueHong, Jun YoungLim, JaechulHwang, Jae YeonChung, Jean-JuYan, QinLiu, YanshengChoi, JungminWysolmerski, John
Issue Date
28-Dec-2021
Publisher
Cell Press
Keywords
HER2; lipid rafts; MAL2; membrane protrusions
Citation
Cell Reports, v.37, no.13
Indexed
SCIE
SCOPUS
Journal Title
Cell Reports
Volume
37
Number
13
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55055
DOI
10.1016/j.celrep.2021.110160
ISSN
2211-1247
Abstract
The lipid raft-resident protein, MAL2, has been implicated as contributing to the pathogenesis of several malignancies, including breast cancer, but the underlying mechanism for its effects on tumorigenesis is unknown. Here, we show that MAL2-mediated lipid raft formation leads to HER2 plasma membrane retention and enhanced HER2 signaling in breast cancer cells. We demonstrate physical interactions between HER2 and MAL2 in lipid rafts using proximity ligation assays. Super-resolution structured illumination microscopy imaging displays the structural organization of the HER2/Ezrin/NHERF1/PMCA2 protein complex. Formation of this protein complex maintains low intracellular calcium concentrations in the vicinity of the plasma membrane. HER2/MAL2 protein interactions in lipid rafts are enhanced in trastuzumab-resistant breast cancer cells. Our findings suggest that MAL2 is crucial for lipid raft formation, HER2 signaling, and HER2 membrane stability in breast cancer cells, suggesting MAL2 as a potential therapeutic target.
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