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Association of preterm birth with medications: machine learning analysis using national health insurance data

Authors
Lee, Kwang-SigSong, In-SeokKim, Eun SunKim, Hae-InAhn, Ki Hoon
Issue Date
May-2022
Publisher
Springer Verlag
Keywords
Preterm birth; Proton pump inhibitors; Sleeping pills; Antidepressants
Citation
Archives of Gynecology and Obstetrics, v.305, no.5, pp.1369 - 1376
Indexed
SCIE
SCOPUS
Journal Title
Archives of Gynecology and Obstetrics
Volume
305
Number
5
Start Page
1369
End Page
1376
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55192
DOI
10.1007/s00404-022-06405-7
ISSN
0932-0067
Abstract
Purpose To use machine learning and population data for testing the associations of preterm birth with socioeconomic status, gastroesophageal reflux disease (GERD) and medication history including proton pump inhibitors, sleeping pills and antidepressants. Methods Population-based retrospective cohort data came from Korea National Health Insurance Service claims data for all women who aged 25-40 years and gave births for the first time as singleton pregnancy during 2015-2017 (405,586 women). The dependent variable was preterm birth during 2015-2017 and 65 independent variables were included (demographic/socioeconomic determinants, disease information, medication history, obstetric information). Random forest variable importance (outcome measure) was used for identifying major determinants of preterm birth and testing its associations with socioeconomic status, GERD and medication history including proton pump inhibitors, sleeping pills and antidepressants. Results Based on random forest variable importance, major determinants of preterm birth during 2015-2017 were socioeconomic status (645.34), age (556.86), proton pump inhibitors (107.61), GERD for the years 2014, 2012 and 2013 (106.78, 105.87 and 104.96), sleeping pills (97.23), GERD for the years 2010, 2011 and 2009 (95.56, 94.84 and 93.81), and antidepressants (90.13). Conclusion Preterm birth has strong associations with low socioeconomic status, GERD and medication history such as proton pump inhibitors, sleeping pills and antidepressants. For preventing preterm birth, appropriate medication would be needed alongside preventive measures for GERD and the promotion of socioeconomic status for pregnant women.
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2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
2. Clinical Science > Department of Oral and Maxillofacial Surgery > 1. Journal Articles
4. Research institute > Institute of Human Behavior and Genetics > 1. Journal Articles

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