18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment
- Authors
- Chun, Min Young; Lee, Jongmin; Jeong, Jee Hyang; Roh, Jee Hoon; Oh, Seung Jun; Oh, Minyoung; Oh, Jungsu S.; Kim, Jae Seung; Moon, Seung Hwan; Woo, Sook-young; Kim, Young Ju; Choe, Yeong Sim; Kim, Hee Jin; Na, Duk L.; Jang, Hyemin; Seo, Sang Won
- Issue Date
- Mar-2022
- Publisher
- Yonsei University College of Medicine
- Keywords
- Positron emission tomography; mild cognitive impairment; amyloid; tau proteins; inflammation
- Citation
- Yonsei Medical Journal, v.63, no.3, pp 259 - 264
- Pages
- 6
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Yonsei Medical Journal
- Volume
- 63
- Number
- 3
- Start Page
- 259
- End Page
- 264
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55213
- DOI
- 10.3349/ymj.2022.63.3.259
- ISSN
- 0513-5796
1976-2437
- Abstract
- Purpose
Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline. 18F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer’s disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ–) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer’s disease pathophysiology. Accordingly, we investigated associations between 18F-THK5351 PET positivity and cognitive decline among Aβ– aMCI patients.
Materials and Methods
The present study included 25 amyloid PET negative aMCI patients who underwent a minimum of two follow-up neuropsychological evaluations, including clinical dementia rating-sum of boxes (CDR-SOB). The patients were classified into two groups: 18F-THK5351-positive and -negative groups. The present study used a linear mixed effects model to estimate the effects of 18F-THK5351 PET positivity on cognitive prognosis among Aβ– aMCI patients.
Results
Among the 25 Aβ– aMCI patients, 10 (40.0%) were 18F-THK5351 positive. The patients in the 18F-THK5351-positive group were older than those in the 18F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years; p<0.001). There was no difference between the two groups with regard to the proportion of apolipoprotein E ε4 carriers. Interestingly, however, the CDR-SOB scores of the 18F-THK5351-positive group deteriorated at a faster rate than those of the 18F-THK5351-negative group (B=0.003, p=0.033).
Conclusion
The results of the present study suggest that increased 18F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ– aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498).
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Collections - 1. Basic Science > Department of Physiology > 1. Journal Articles
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