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Epstein-Barr virus-encoded latent membrane protein 1 induces epithelial to mesenchymal transition by inducing V-set Ig domain containing 4 (VSIG4) expression via NF-kB in renal tubular epithelial HK-2 cells

Authors
Kim S.-M.Oh S.W.Park S.H.Hur D.Y.Hong S.-W.Han S.Y.
Issue Date
2017
Publisher
Academic Press
Keywords
EBV; EMT; LMP1; NF-kB; Renal tubular cell; VSIG4
Citation
Biochemical and Biophysical Research Communications, v.492, no.3, pp 316 - 322
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
Biochemical and Biophysical Research Communications
Volume
492
Number
3
Start Page
316
End Page
322
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5639
DOI
10.1016/j.bbrc.2017.08.116
ISSN
0006-291X
1090-2104
Abstract
The epithelial to mesenchymal transition (EMT), a hallmark of chronic kidney disease, is a key event in the conversion from tubular epithelial cells to myofibroblasts in renal fibrosis. Epstein-Barr virus (EBV) is a γ-herpes oncovirus associated with chronic kidney disease. However, the relationship between EBV and the EMT process in renal tubular epithelial cells is not well understood. Among EBV-latent genes, EBV-encoded latent membrane protein 1 (LMP1) induces EMT by regulating a variety of molecules in EBV-induced oncogenic transformation. In this study, we investigated EBV-encoded LMP1 and EMT process markers in human proximal tubule epithelial cell line HK-2. LMP1 overexpression induces cell morphological changes via the epithelial to mesenchymal process in HK-2 cells, and these changes accelerate cell proliferation, cell motility, and invasion. Furthermore, VSIG4 upregulation by EBV-LMP1 induced LMP1-mediated EMT, cell motility, and invasion. VSIG4 upregulation by LMP1 was regulated at the transcriptional level via the NF-kB signaling axis. These results suggest that EBV-encoded LMP1 regulates EMT through the NF-kB-VSIG4 axis in HK-2 cells, and VSIG4 is a potential target in EBV-induced chronic kidney diseases. © 2017 Elsevier Inc.
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Oh, Se Won
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
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