Comparative study of dual-pulsed 1064 nm Q-switched Nd:YAG laser and single-pulsed 1064 nm Q-switched Nd: YAG laser by using zebrafish model and prospective split-face analysis of facial melasma
- Authors
- Jang, Hee Won; Chun, Seung Hyun; Park, Hae Chul; Ryu, Hwa Jung; Kim, Il-Hwan
- Issue Date
- 2017
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Nd: YAG; zebrafish; melasma
- Citation
- JOURNAL OF COSMETIC AND LASER THERAPY, v.19, no.2, pp 114 - 123
- Pages
- 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF COSMETIC AND LASER THERAPY
- Volume
- 19
- Number
- 2
- Start Page
- 114
- End Page
- 123
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5695
- DOI
- 10.1080/14764172.2016.1262958
- ISSN
- 1476-4172
1476-4180
- Abstract
- Background: Recently dual-pulsed low-fluence 1064-nm Q-switched Nd: YAG (QSNY) laser has been developed for reducing complication during melasma treatment. Objective: Comparison of the efficacy and safety between dual-pulsed mode and single-pulsed mode for the treatment of melasma. Materials and methods: In preclinical study, adult zebrafish were irradiated with dual-pulsed and single-pulsed mode. Changes of melanophore and cell death were assessed. In split-face clinical study, dual-pulsed and single-pulsed mode were irradiated on the left and right side of the face, respectively. L* value, clinical digital photos, modified Melasma Area and Severity Index (MASI) scores, and side effects were measured. Results: As compared to single-pulsed mode and dual-pulsed mode with longer intervals, zebrafish melanophore was cleared quickly at dual-pulsed mode with 80-mu sec interval and 0.3 J/cm(2) fluence. Dual-pulsed mode showed the least regeneration of melanophore at 4 weeks after irradiation and no cell death was observed with 80-mu sec interval. Both pulse modes improved melasma significantly but modified MASI score and L* value were not significantly different between each other. Lesser pain and shorter duration of post-laser erythema were observed with dual-pulsed mode. Conclusion: Dualpulsed mode was as effective as single-pulsed mode for the treatment of melasma and revealed less side effects.
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- Appears in
Collections - 2. Clinical Science > Department of Dermatology > 1. Journal Articles
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