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Cited 6 time in webofscience Cited 11 time in scopus
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Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitisopen access

Authors
Kim, Hee YeonKim, Chang WookKim, Tae YeobSong, Do SeonSinn, Dong HyunYoon, Eileen L.Jung, Young KulSuk, Ki TaeLee, Sang SooLee, Chang HyeongKim, Tae HunKim, Jeong HanYim, Hyung JoonKim, Sung EunBaik, Soon KooLee, Byung SeokJang, Jae YoungKim, Young SeokKim, Sang GyuneYang, Jin MoSohn, Joo HyunLee, Heon JuPark, Seung HaChoi, Eun HeeKim, Dong Joon
Issue Date
7-Nov-2016
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
Acute-on-chronic liver failure; Alcoholic hepatitis; Mortality; Prognosis; Scoring system
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.22, no.41, pp.9205 - 9213
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
22
Number
41
Start Page
9205
End Page
9213
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5846
DOI
10.3748/wjg.v22.i41.9205
ISSN
1007-9327
Abstract
AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting short-term mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey'sdiscriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.
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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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