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Cited 19 time in webofscience Cited 21 time in scopus
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RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer

Authors
Kim, Bo RamKang, Myoung HeeKim, Jung LimNa, Yoo JinPark, Seong HyeLee, Sun IlKang, SangheeJoung, Sung YupLee, Suk-YoungLee, Dae-HeeMin, Byung WookOh, Sang Cheul
Issue Date
Nov-2016
Publisher
Demetrios A. Spandidos Ed. & Pub.
Keywords
colorectal cancer; runt-related transcription factor 3; migration; angiogenesis; VEGF
Citation
Oncology Reports, v.36, no.5, pp.2601 - 2608
Indexed
SCIE
SCOPUS
Journal Title
Oncology Reports
Volume
36
Number
5
Start Page
2601
End Page
2608
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5882
DOI
10.3892/or.2016.5086
ISSN
1021-335X
Abstract
Recent studies have determined that inactivation of runt-related transcription factor 3 (RUNX3) expression is highly associated with lymph node metastasis and poor prognosis in various types of cancer. However, the mechanism of RUNX3-mediated suppression of tumor metastasis remains unclear. Herein, we aimed to clarify the effect of RUNX3 on metastasis and angiogenesis in colorectal cancer (CRC). Firstly, we found that the reduction in expression of RUNX3 in CRC tissues when compared with tumor adjacent normal colon tissues, as indicated by reduced RUNX3 staining, was significantly correlated with tumor-node-metastasis (TNM) stage. Secondly, we demonstrated that RUNX3 overexpression inhibited CRC cell migration and invasion resulting from the upregulation of matrix metalloproteinase-2 (MMP-2) and MMP-9 expression. In contrast, the knockdown of RUNX3 reduced the inhibition of migration and invasion of CRC cells. Finally, we found that restoration of RUNX3 decreased vascular endothelial growth factor (VEGF) secretion and suppressed endothelial cell growth and tube formation in CRC cells. All in all, our findings may provide insight into the development of RUNX3 for CRC metastasis diagnostics and therapeutics.
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2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
3. Graduate School > Graduate School > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles

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Oh, Sang Cheul
Guro Hospital (Department of Medical Oncology and Hematology, Guro Hospital)
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