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Cited 4 time in webofscience Cited 15 time in scopus
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The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Studyopen access

Authors
Hong, Su JinPark, Soo-HeonMoon, Jeong SeopShin, Woon GeonKim, Jae GyuLee, Yong ChanLee, Dong HoJang, Jae YoungKim, Jae J.Lee, Hang-LakLee, Sang WooHwangbo, YoungXu, JianmingWang, BangmaoXue, ZhanxiongLiu, FeiYuan, YaozongLeelakusolvong, SomchaiDy, Frederick
Issue Date
Nov-2016
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Peptic esophagitis; Symptoms; Heartburn; Rebamipide; Esomeprazole
Citation
GUT AND LIVER, v.10, no.6, pp.910 - 916
Indexed
SCIE
SCOPUS
KCI
Journal Title
GUT AND LIVER
Volume
10
Number
6
Start Page
910
End Page
916
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5943
DOI
10.5009/gnl15537
ISSN
1976-2283
Abstract
Background/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results: The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1 +/- 13.8 in the combination therapy group and -15.1 +/- 11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4 +/- 6.6 in the combination therapy group and -6.8 +/- 5.9 in the monotherapy group (p=0.009). Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.
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Lee, Sang Woo
안산병원 (Department of Gastroenterology and Hepatology, Ansan Hospital)
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